Lauterburg B H
Institut für Pharmakologie, Universität Bern.
Ther Umsch. 1992 May;49(5):326-32.
Alcoholic hepatitis presents as an acute hepatitis in an alcoholic. No specific laboratory tests for alcoholic hepatitis exist. Therefore, the diagnosis must be based on the clinical presentation, histology and exclusion of other causes of a similar clinical picture such as viruses and drugs. Patients with elevated bilirubin, encephalopathy and coagulopathy have a poor prognosis. Steroids, infusion of insulin and glucagon, supplementation of amino-acids and other experimental therapies do not appear to be helpful with the exception of steroids which may benefit the sickest patients. Long-term prognosis depends on the extent of cirrhotic changes present after the acute episode and on the drinking habits of the patient.
酒精性肝炎表现为酗酒者的急性肝炎。目前尚无针对酒精性肝炎的特异性实验室检查。因此,诊断必须基于临床表现、组织学检查,并排除其他具有类似临床表现的病因,如病毒和药物。胆红素升高、肝性脑病和凝血功能障碍的患者预后较差。除了可能对病情最严重的患者有益的类固醇外,类固醇、胰岛素和胰高血糖素输注、氨基酸补充及其他实验性治疗似乎并无帮助。长期预后取决于急性发作后肝硬化改变的程度以及患者的饮酒习惯。