Tang Xiao Lei, Smith Trevor Rf, Kumar Vipin
Laboratory of Autoimmunity, Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA.
Cell Mol Immunol. 2005 Feb;2(1):11-9.
T lymphocytes with dedicated suppressor function (Treg) play a crucial role in the homeostatic control of immunity in the periphery. Several Treg phenotypes have now been identified in the CD4 and CD8 T cell populations, suggesting their down-regulatory function in both human and animal models of autoimmunity, transplantation and tumor immunity. Here we will focus on the CD8 Treg population and their ability to specifically inhibit a pathogenic autoimmune response. This review will detail the current advances in the knowledge of CD8 Treg in the context of antigen specificity, phenotype, MHC restriction, mechanism of action, and priming.
具有专门抑制功能的T淋巴细胞（Treg）在外周免疫的稳态控制中发挥着关键作用。目前已在CD4和CD8 T细胞群体中鉴定出几种Treg表型，这表明它们在自身免疫、移植和肿瘤免疫的人类及动物模型中均具有下调功能。在此，我们将重点关注CD8 Treg群体及其特异性抑制致病性自身免疫反应的能力。本综述将详细阐述在抗原特异性、表型、MHC限制、作用机制和启动方面，目前关于CD8 Treg的知识进展。
