Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
Front Immunol. 2021 Jan 28;11:602823. doi: 10.3389/fimmu.2020.602823. eCollection 2020.
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease associated with damage to multiple organs and glands. The most common clinical manifestations are dry eyes, dry mouth, and enlarged salivary glands. Currently, CD4 T lymphocytes are considered to be key factors in the immunopathogenesis of pSS, but various studies have shown that CD8 T lymphocytes contribute to acinar injury in the exocrine glands. Therefore, in this review, we discussed the classification and features of CD8 T lymphocytes, specifically describing the role of CD8 T lymphocytes in disease pathophysiology. Furthermore, we presented treatment strategies targeting CD8 T cells to capitalize on the pathogenic and regulatory potential of CD8 T lymphocytes in SS to provide promising new strategies for this inflammatory disease.
原发性干燥综合征（pSS）是一种与多器官和腺体损伤相关的慢性自身免疫性疾病。最常见的临床症状为眼干、口干和唾液腺肿大。目前，CD4 T 淋巴细胞被认为是 pSS 免疫发病机制的关键因素，但多项研究表明 CD8 T 淋巴细胞也参与了外分泌腺的腺泡损伤。因此，在本综述中，我们讨论了 CD8 T 淋巴细胞的分类和特征，具体描述了 CD8 T 淋巴细胞在疾病病理生理学中的作用。此外，我们提出了针对 CD8 T 细胞的治疗策略，以利用 SS 中 CD8 T 淋巴细胞的致病和调节潜力，为这种炎症性疾病提供有前景的新策略。
