Huang Ying Su, Misior Anna, Li Li Wu
Department of Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.
Cell Mol Immunol. 2005 Feb;2(1):36-9.
The interleukin-1 receptor associated kinases (IRAKs) sit at the bottle neck for the Toll-like-receptor (TLR) mediated signal transduction process controlling host innate immune response. However, the exact role and regulation of IRAKs are still in the early stage and not fully understood. This review intends to summarize the recent advancement in this important topic and point out areas that need further intensive investigation.
白细胞介素-1受体相关激酶（IRAKs）处于Toll样受体（TLR）介导的控制宿主天然免疫反应的信号转导过程的瓶颈位置。然而，IRAKs的确切作用和调控仍处于早期阶段，尚未完全了解。本综述旨在总结这一重要课题的最新进展，并指出需要进一步深入研究的领域。
