Miggin Sinead M, O'Neill Luke A J
School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.
J Leukoc Biol. 2006 Aug;80(2):220-6. doi: 10.1189/jlb.1105672. Epub 2006 May 12.
Toll-like receptor (TLR) activation is dictated by a number of factors including the ligand itself and the localization of the receptor, in terms of expression profile and subcellular localization and the signal transduction pathway that has been activated. Recent work into TLR signal transduction has revealed complex regulation at a number of different levels including regulation by phosphorylation, targeted degradation, and sequestration of signaling molecules. Here, we describe recent advances that have been made in our understanding of how TLR signaling is regulated at the biochemical level.
Toll样受体（TLR）的激活取决于多种因素，包括配体本身、受体的定位（就表达谱和亚细胞定位而言）以及已被激活的信号转导途径。最近对TLR信号转导的研究揭示了在多个不同水平上的复杂调控，包括通过磷酸化、靶向降解和信号分子隔离进行的调控。在这里，我们描述了在理解TLR信号在生化水平上如何被调控方面所取得的最新进展。
