Wee Jamie, Charlton Catherine, Simpson Helen, Jackson Nicola C, Shojaee-Moradie Fariba, Stolinski Michael, Pentecost Claire, Umpleby A Margot
Department of Diabetes, Endocrinology and Internal Medicine, St. Thomas' Hospital, GKT School of Medicine, Kings College, London, UK.
Growth Horm IGF Res. 2005 Dec;15(6):397-404. doi: 10.1016/j.ghir.2005.08.003. Epub 2005 Oct 5.
Exercise is a potent stimulator of growth hormone (GH) secretion. We hypothesised that after a short bout of intense exercise GH may increase lipolysis during recovery. In 7 moderately trained young male subjects (21.8 +/- 0.5 years) and 7 moderately trained older male subjects (56.0 +/- 1.0 years) [(2)H(5)] glycerol was infused for 370min to measure glycerol production rate (R(a)), a measure of lipolysis. At 130 min subjects exercised on a cycle ergonometer for 20 min at 70% V(O2 max), followed by rest for 220 min. On a separate occasion the study was repeated in the young subjects with a 1h GH infusion (4microgkg(-1)h(-1)) at 130 min instead of exercise. In response to exercise, catecholamines (p < 0.02) and glycerol R(a) (p < 0.01) increased, peaking during exercise. GH concentration increased in response to exercise (p < 0.01), peaking after exercise (150-160 min) in both groups with no significant difference in peak response between groups. A post-exercise rise in glycerol R(a) was demonstrated in both groups peaking at 265-295 min in the older group (p < 0.002, peak vs. basal) and continuing to rise until 370 min in the young group (p < 0.01, peak vs. basal). The timing and magnitude of this was reproduced with the GH infusion. There was a significant correlation between the peak GH response to exercise and the post-exercise rise in glycerol R(a) measured as area under the curve (r=0.57, p < 0.04). In conclusion, this study provides evidence that the GH response to acute exercise may increase lipolysis during recovery.
运动是生长激素（GH）分泌的有力刺激因素。我们推测，短时间的剧烈运动后，GH可能会在恢复过程中增加脂肪分解。在7名训练有素的年轻男性受试者（21.8±0.5岁）和7名训练有素的老年男性受试者（56.0±1.0岁）中，输注[（2）H（5）]甘油370分钟以测量甘油生成率（R（a）），这是脂肪分解的一项指标。在130分钟时，受试者在自行车测力计上以70%的最大摄氧量（V（O2 max））运动20分钟，随后休息220分钟。在另一个场合，年轻受试者重复该研究，在130分钟时输注生长激素1小时（4μg·kg（-1）·h（-1））而非进行运动。运动后，儿茶酚胺（p<0.02）和甘油R（a）（p<0.01）增加，在运动期间达到峰值。两组运动后生长激素浓度均增加（p<0.01），在运动后（150 - 160分钟）达到峰值，两组峰值反应无显著差异。两组运动后甘油R（a）均升高，老年组在265 - 295分钟达到峰值（p<0.002，峰值与基础值相比），年轻组持续升高直至370分钟（p<0.01，峰值与基础值相比）。生长激素输注可重现这种变化的时间和幅度。运动后生长激素峰值反应与运动后甘油R（a）升高（以曲线下面积衡量）之间存在显著相关性（r = 0.57，p<0.04）。总之，本研究提供了证据表明，急性运动后生长激素反应可能会在恢复过程中增加脂肪分解。
