Soriguer Escofet F J, Sebastián Gil D, Campos Arillo V, Esteva de Antonio I, Romero Arias J A, Reina Cobos G, García Arnes J, Ruiz de Adana S, Martín Chazos F, Mazuecos F
Unidad de Endocrinología y Servicio de Respiratorio, Hospital Regional Carlos Haya, Málaga.
Med Clin (Barc). 1992 Apr 25;98(16):601-6.
The increase of the growth hormone (GH) during exercise is known although the relationship of this response with other hormones, the type and intensity of the exercise, nutritional state and with the degree of training are reasons for discussion. The aim of this investigation was to study the response of the HG on a group of young adults with different degrees of training, according to the maximum consumption of oxygen (VO2 max) achieved over a short period of time.
Thirty-nine healthy subjects who underwent maximum effort on the treadmill were grouped according to VO2 max reached (less than 3,000 ml/min; 3,000-4,500 ml/min and greater than 4,500 ml/min). Systolic blood pressure (SBP) and diastolic blood pressure (DBP), respiratory quotient (RQ), O2 pulse, cardiac frequency (CF) respiratory equivalence (RE), glycemia, plasma insulin (PI), C peptide, lactic acid, venous pH, plasma renin activity (PRA), plasma aldosterone, thyrotropine (TSH), triodothyronine (T3), thyroxine (T4), adrenocorticotropine (ACTH), cortisol and GH were measured basally and following achievement of VO2 max.
The GH was only increased in those subjects with a VO2 max higher than 3,000 ml/min with a significant positive correlation found between the GH and VO2 max and a significant negative correlation was found between the GH and lactic acid at the end of the test. The increase of glycemia at the end of the test correlated with the VO2 max. The PI and C peptide increased at the end of the test in the subjects with greater VO2 max capacity and correlated positively with the VO2 max and with the GH upon completion of the exercise.
These results suggest that the response of the growth hormone to exercise is a function of maximum oxygen consumption although this only explains 24% of the variants of the growth hormone. Despite important hormonal and metabolic mobilization during exercise, no model of multiple regression has been found which substantially improves the association found between the growth hormone and maximum oxygen consumption.
运动期间生长激素（GH）会升高，这一点已知，不过这种反应与其他激素、运动类型和强度、营养状况以及训练程度之间的关系仍有待探讨。本研究的目的是根据短期内达到的最大耗氧量（VO2 max），研究一组不同训练程度的年轻成年人中生长激素的反应。
39名在跑步机上进行最大强度运动的健康受试者，根据达到的VO2 max进行分组（低于3000毫升/分钟；3000 - 4500毫升/分钟和高于4500毫升/分钟）。在运动前及达到VO2 max后，测量收缩压（SBP）、舒张压（DBP）、呼吸商（RQ）、氧脉搏、心率（CF）、呼吸当量（RE）、血糖、血浆胰岛素（PI）、C肽、乳酸、静脉血pH值、血浆肾素活性（PRA）、血浆醛固酮、促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）、促肾上腺皮质激素（ACTH）、皮质醇和生长激素。
只有VO2 max高于3000毫升/分钟的受试者生长激素升高，测试结束时生长激素与VO2 max之间存在显著正相关，生长激素与乳酸之间存在显著负相关。测试结束时血糖升高与VO2 max相关。VO2 max能力较强的受试者在测试结束时PI和C肽升高，且与VO2 max以及运动结束时的生长激素呈正相关。
这些结果表明，生长激素对运动的反应是最大耗氧量的函数，尽管这仅解释了生长激素变异的24%。尽管运动期间有重要的激素和代谢动员，但尚未发现多元回归模型能显著改善生长激素与最大耗氧量之间的关联。
