Micmacher E, Conceição F L, Netto L S, Redorat R, Biesek S, Gold J, Cenci M C, Santos M J C F, Taboada G F, Assumpção R, Montenegro F S, Roisman V, Paula S K, Vaisman M
Endocrine Service of Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro - UFRJ - Rio de Janeiro, RJ, Brazil.
Growth Horm IGF Res. 2008 Apr;18(2):143-7. doi: 10.1016/j.ghir.2007.07.010. Epub 2007 Sep 12.
The use of growth hormone (GH) in deficient adults has already been demonstrated to result in several benefits regarding metabolic parameters, body composition and quality of life. Due to the similarities between GH deficiency in adults and the aging process, the concept of somatopause has emerged.
Correlate the GH secretion profile in healthy men older than 50 years with anthropometric parameters and exercise capacity.
Twenty-nine healthy male were selected, with a mean age of 57.9+/-4.2 years (range 50-66). After hospital admission, body mass index (BMI), body composition (fat mass) and abdominal circumference, 24-h GH profile, GH peak and basal IGF-I were evaluated, and all the patients underwent a treadmill stress testing to estimate exercise capacity with the Bruce protocol, with evaluation of the maximum oxygen peak, maximum heart rate and METs. All the results are shown as mean+/-Std deviation: BMI -26.5+/-4.9kg/m2, percent fat mass -27.1+/-6.2%, abdominal circumference -92.1+/-10.1cm, 24h GH profile -0.3+/-0.2ng/dl, peak GH -2.5+/-2.0ng/dl, IGF-I -202.4+/-72.4ng/dl, maximum oxygen peak -31.9+/-6.8L, maximum heart rate - 161.4+/-7.5 bpm and METs - 9.1+/-1.9. After regression analysis using the GH secretion profile (mean GH in 24h, spontaneous peak GH and basal IGF-I) as dependent variable, no correlations were found between these and the other evaluated parameters.
已证实生长激素（GH）用于成年缺乏者可在代谢参数、身体成分和生活质量方面带来诸多益处。由于成年人生长激素缺乏与衰老过程存在相似性，“生长停滞期”的概念应运而生。
将50岁以上健康男性的生长激素分泌情况与人体测量参数和运动能力相关联。
选取29名健康男性，平均年龄57.9±4.2岁（范围50 - 66岁）。入院后，评估体重指数（BMI）、身体成分（脂肪量）和腹围、24小时生长激素分泌情况、生长激素峰值和基础胰岛素样生长因子-I（IGF-I），所有患者均接受跑步机压力测试，采用布鲁斯方案评估运动能力，评估最大氧峰值、最大心率和代谢当量。所有结果均以平均值±标准差表示：BMI - 26.5±4.9kg/m²，脂肪量百分比 - 27.1±6.2%，腹围 - 92.1±10.1cm，24小时生长激素分泌情况 - 0.3±0.2ng/dl，生长激素峰值 - 2.5±2.0ng/dl，IGF-I - 202.4±72.4ng/dl，最大氧峰值 - 31.9±6.8L，最大心率 - 161.4±7.5次/分钟，代谢当量 - 9.1±1.9。以生长激素分泌情况（24小时平均生长激素、自发生长激素峰值和基础IGF-I）作为因变量进行回归分析后，未发现这些指标与其他评估参数之间存在相关性。
