Magne David, Vinatier Claire, Julien Marion, Weiss Pierre, Guicheux Jérôme
INSERM EM 99-03, 1 place A. Ricordeau, 44042 Nantes Cedex 1, France.
Trends Mol Med. 2005 Nov;11(11):519-26. doi: 10.1016/j.molmed.2005.09.002. Epub 2005 Oct 5.
Disorders affecting cartilage touch almost the whole population and are one of the leading causes of invalidity in adults. To repair cartilage, therapeutic approaches initially focused on the implantation of autologous chondrocytes, but this technique proved unsatisfactory because of the limited number of chondrocytes obtained at harvest. The discovery that several adult human tissues contain mesenchymal stem cells (MSCs) capable of differentiating into chondrocytes raised the possibility of injecting MSCs to repair cartilages. The important data published recently on the factors controlling chondrocyte commitment must be thoroughly considered to make further progress towards this therapeutic approach. The potential application of MSC therapy provides new hope for the development of innovative treatments for the repair of cartilage disorders.
影响软骨的疾病几乎涉及全体人群，并且是成年人致残的主要原因之一。为了修复软骨，治疗方法最初集中于自体软骨细胞移植，但由于取材时获得的软骨细胞数量有限，该技术被证明并不理想。几种成人组织中含有能够分化为软骨细胞的间充质干细胞（MSC）这一发现，增加了通过注射MSC来修复软骨的可能性。为了在这种治疗方法上取得进一步进展，必须全面考虑最近发表的关于控制软骨细胞定向分化因素的重要数据。MSC疗法的潜在应用为开发治疗软骨疾病的创新疗法带来了新希望。
