Machida Yuichi J, Hamlin Joyce L, Dutta Anindya
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Cell. 2005 Oct 7;123(1):13-24. doi: 10.1016/j.cell.2005.09.019.
DNA replication is tightly regulated at the initiation step by both the cell cycle machinery and checkpoint pathways. Here, we discuss recent advances in understanding how replication is initiated in metazoans at the correct chromosome positions, at the appropriate time, and only once per cell cycle.
DNA复制在起始步骤受到细胞周期机制和检查点通路的严格调控。在此，我们讨论了在理解后生动物中复制如何在正确的染色体位置、在合适的时间且每个细胞周期仅起始一次方面的最新进展。
