Derner Richard, Anderson Ann C
Clin Podiatr Med Surg. 2005 Oct;22(4):607-18, vii. doi: 10.1016/j.cpm.2005.07.005.
The molecular and cellular process to promote bone formation has been examined extensively in recent years in an attempt to minimize delayed unions and nonunions. Bone morphogenetic proteins (BMPs) have been determined to play an intricate role in the bone formation cascade. Over 14 BMPs have been isolated and more are being discovered as investigation progresses. BMP-2 and BMP-7 are being produced commercially for clinical use with specific indications. Continuing research is investigating the optimal carrier that will give the best results. This article reviews the most current information regarding BMPs.
近年来，为了尽量减少延迟愈合和骨不连的发生，人们对促进骨形成的分子和细胞过程进行了广泛研究。骨形态发生蛋白（BMPs）已被确定在骨形成级联反应中发挥复杂作用。已分离出14种以上的BMPs，随着研究的进展，更多的BMPs正在被发现。BMP-2和BMP-7正在商业化生产以供特定适应症的临床使用。持续的研究正在探索能产生最佳效果的最佳载体。本文综述了有关BMPs的最新信息。
