Marques Catarina, Ferreira José M F, Andronescu Ecaterina, Ficai Denisa, Sonmez Maria, Ficai Anton
Department of Materials and Ceramics Engineering, Centre for Research in Ceramics and Composite Materials, University of Aveiro, Aveiro, Portugal.
Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, Bucharest, Romania.
Int J Nanomedicine. 2014 May 28;9:2713-25. doi: 10.2147/IJN.S55943. eCollection 2014.
The purpose of this review is to present the most recent findings in bone tissue engineering. Special attention is given to multifunctional materials based on collagen and collagen-hydroxyapatite composites used for skin and bone cancer treatments. The multi-functionality of these materials was obtained by adding to the base regenerative grafts proper components, such as ferrites (magnetite being the most important representative), cytostatics (cisplatin, carboplatin, vincristine, methotrexate, paclitaxel, doxorubicin), silver nanoparticles, antibiotics (anthracyclines, geldanamycin), and/or analgesics (ibuprofen, fentanyl). The suitability of complex systems for the intended applications was systematically analyzed. The developmental possibilities of multifunctional materials with regenerative and curative roles (antitumoral as well as pain management) in the field of skin and bone cancer treatment are discussed. It is worth mentioning that better materials are likely to be developed by combining conventional and unconventional experimental strategies.
本综述的目的是介绍骨组织工程的最新研究成果。特别关注基于胶原蛋白和用于皮肤及骨癌治疗的胶原-羟基磷灰石复合材料的多功能材料。这些材料的多功能性是通过向基础再生移植物中添加适当的成分来实现的，例如铁氧体（磁铁矿是最重要的代表）、细胞抑制剂（顺铂、卡铂、长春新碱、甲氨蝶呤、紫杉醇、阿霉素）、银纳米颗粒、抗生素（蒽环类抗生素、格尔德霉素）和/或镇痛药（布洛芬、芬太尼）。系统分析了复杂系统在预期应用中的适用性。讨论了多功能材料在皮肤和骨癌治疗领域具有再生和治疗作用（抗肿瘤以及疼痛管理）的发展可能性。值得一提的是，通过结合传统和非传统的实验策略，可能会开发出更好的材料。
