Alissa Eman M, Bahjri Suhad M, Al-Ama Nabeel, Ahmed Waqar H, Ferns Gordon A A
Faculty of Medicine, King Abdul Aziz University, PO Box 12713, Jeddah 21483, Kingdom of Saudi Arabia.
Clin Chim Acta. 2006 Mar;365(1-2):288-96. doi: 10.1016/j.cca.2005.09.007. Epub 2005 Oct 6.
The relationship between coronary risk score (CRS), individual coronary risk factors and the serum inflammatory markers, high sensitivity C-reactive protein (hsCRP), ceruloplasmin (Cp), and soluble intercellular adhesion molecule-1 (sICAM-1) was studied in 140 Saudi males without clinically evident coronary heart disease (CHD).
One hundred forty subjects without clinically evident CHD were categorized into age tertiles. Demographic data together with an estimate of CRS using Framingham and PROCAM algorithms were obtained, and serum lipid profile, glucose, hsCRP, sICAM-1, and Cp were measured. Macronutrient intake was assessed by a questionnaire. The relationship between CRS, biochemical markers and diet was assessed by univariate and multivariate analysis.
There was no significant difference in median hsCRP, sICAM-1 or Cp between the age groups. Serum Cp was positively associated with age (r=0.224, p<0.01) and FRS score (r=0.174, p<0.05). Serum sICAM-1 was negatively associated with PROCAM score (r=-0.183, p<0.05). sICAM-1 was positively associated with HDL cholesterol (r=0.36, p<0.0001) among non-diabetics and negatively associated (r=-0.397, p<0.05) among diabetic subjects. Age and dietary intake of saturated fatty acids together explained 7.9% of the variation in serum Cp level in a stepwise multiple regression model. Similarly 6.5% of the variation in serum sICAM-1 level was explained by the total cholesterol/HDL-C ratio. The youngest tertile of the group (<30 y) had the highest dietary intake of energy, fat and saturated fatty acids (p<0.05), and also had a high prevalence of obesity, smoking and sedentary lifestyle.
We have demonstrated that there is a high prevalence of coronary risk factors and poor dietary intake within a Saudi male population, and that dietary factors are associated with serum sICAM-1 and ceruloplasmin but not hsCRP concentrations in this group.
在140名无临床明显冠心病（CHD）的沙特男性中，研究了冠状动脉风险评分（CRS）、个体冠状动脉风险因素与血清炎症标志物高敏C反应蛋白（hsCRP）、铜蓝蛋白（Cp）和可溶性细胞间黏附分子-1（sICAM-1）之间的关系。
将140名无临床明显CHD的受试者按年龄分为三个三分位数组。获取人口统计学数据以及使用弗雷明汉和PROCAM算法估算的CRS，并测量血清脂质谱、血糖、hsCRP、sICAM-1和Cp。通过问卷调查评估常量营养素摄入量。通过单变量和多变量分析评估CRS、生化标志物与饮食之间的关系。
各年龄组之间hsCRP、sICAM-1或Cp的中位数无显著差异。血清Cp与年龄呈正相关（r = 0.224，p < 0.01）和FRS评分呈正相关（r = 0.174，p < 0.05）。血清sICAM-1与PROCAM评分呈负相关（r = -0.183，p < 0.05）。在非糖尿病患者中，sICAM-1与高密度脂蛋白胆固醇呈正相关（r = 0.36，p < 0.0001），而在糖尿病患者中呈负相关（r = -0.397，p < 0.05）。在逐步多元回归模型中，年龄和饱和脂肪酸的饮食摄入量共同解释了血清Cp水平变化的7.9%。同样，总胆固醇/高密度脂蛋白胆固醇比值解释了血清sICAM-1水平变化的6.5%。该组最年轻的三分位数组（<30岁）能量、脂肪和饱和脂肪酸的饮食摄入量最高（p < 0.05），肥胖、吸烟和久坐生活方式的患病率也很高。
我们已经证明，沙特男性人群中冠状动脉风险因素的患病率很高，饮食摄入不良，并且饮食因素与该组血清sICAM-1和铜蓝蛋白有关，但与hsCRP浓度无关。
