Farmakis E, Puntis J W, Toumba K J
Dept Paediatric Dentistry, University of Leeds, England.
Eur J Paediatr Dent. 2005 Sep;6(3):129-32.
This was to investigate the prevalence of enamel developmental defects in a group of children with a history of coeliac disease.
A study group of children attending the Dept. Paediatrics (Leeds General Infirmary), born between 1985 and 1986 and subsequently diagnosed and treated for coeliac disease (CD) were recruited. A group of age/sex-matched children attending the Paediatric Dentistry department were used as a control group (Cont). Examinations were carried out for enamel defects and opacities (DDE index), dmf, dmfs, DMF and DMFS (BASCD method), and a full medical and dental history were obtained.
Significantly more children in the CD group had a greater number of enamel defects than controls for both primary (p=<0.02) and permanent (p=<0.001) dentitions. Opacities in both primary and permanent teeth were statistically significantly greater in the CD group than controls (p=<0.04 and p=<0.001 respectively). Dental caries in both primary and permanent dentitions was less in the CD group compared with the control group of children.
Coeliac disease was associated with an increased prevalence of developmental enamel defects.
本研究旨在调查一组患有乳糜泻病史儿童的釉质发育缺陷患病率。
招募了一组于1985年至1986年间出生、随后被诊断并接受乳糜泻（CD）治疗的儿科（利兹综合医院）就诊儿童作为研究组。将一组在儿童牙科就诊的年龄/性别匹配儿童作为对照组（Cont）。对釉质缺陷和不透明度（DDE指数）、dmf、dmfs、DMF和DMFS（BASCD方法）进行检查，并获取完整的医学和牙科病史。
无论是乳牙列（p<0.02）还是恒牙列（p<0.001），CD组中釉质缺陷数量显著多于对照组。CD组乳牙和恒牙的不透明度在统计学上均显著高于对照组（分别为p<0.04和p<0.001）。与对照组儿童相比，CD组乳牙列和恒牙列的龋齿均较少。
乳糜泻与发育性釉质缺陷患病率增加有关。
