Sarkozy Andrea, Caenepeel Axel, Geelen Peter, Peytchev Peter, de Zutter Marc, Brugada Pedro
Cardiovascular Research and Teaching Institute, Aalst Cardiovascular Center, OLV Hospital, Moorselbaan 164, 9300 Aalst, Belgium.
Europace. 2005 Nov;7(6):537-9. doi: 10.1016/j.eupc.2005.06.013.
We report a case of a 61-year-old female patient who presented with palpitations. The baseline electrocardiogram showed incomplete right bundle branch block with saddle back pattern of the ST segment in one precordial lead, but without any significant ST elevation. She was treated with oral cibenzoline. The subsequent ECG showed a coved Brugada ECG (type I) pattern, which resolved following the discontinuation of cibenzoline. An ajmaline test reproduced the coved type Brugada ECG pattern. Our case is the first report of oral cibenzoline therapy unmasking the diagnostic coved Brugada ECG pattern in a patient with a baseline normal ECG. Cibenzoline, a class I sodium channel blocker antiarrhythmic drug, should probably be avoided in the treatment of patients with Brugada syndrome.
我们报告一例61岁女性患者，其表现为心悸。基线心电图显示不完全性右束支传导阻滞，一个胸前导联ST段呈鞍背型，但无明显ST段抬高。她接受了口服西苯唑啉治疗。随后的心电图显示为穹窿型Brugada心电图（I型）模式，停用西苯唑啉后该模式消失。阿义马林试验再现了穹窿型Brugada心电图模式。我们的病例是第一例关于口服西苯唑啉治疗使基线心电图正常的患者显现出诊断性穹窿型Brugada心电图模式的报告。西苯唑啉是一种I类钠通道阻滞剂抗心律失常药物，在Brugada综合征患者的治疗中可能应避免使用。
