Rault R, Holley J L, Banner B F, el-Shahawy M
Renal-Electrolyte Division, University of Pittsburgh, Presbyterian-University Hospital, PA 15213.
Am J Kidney Dis. 1992 Jul;20(1):84-9. doi: 10.1016/s0272-6386(12)80323-4.
Two cases of glomerulonephritis associated with non-Hodgkin's lymphoma (NHL) are described. The first patient presented with the nephrotic syndrome and normal renal function, whereas the second suffered from recurrent acute renal failure together with a unique pattern of IgM deposition within glomerular capillaries. Our review of the literature suggests that this association, although rare, has been documented in a sufficient number of cases to show that it is more than coincidental. Whereas the most common renal lesion associated with Hodgkin's disease is minimal change disease, more advanced glomerular changes are found in the patients with NHL. This is reflected in the higher incidence of renal failure in the latter patients. Treatment of the lymphomas has been shown to result in improvement or even cure of the renal disease, although long-term follow-up is rarely available in the reported cases.
本文描述了两例与非霍奇金淋巴瘤（NHL）相关的肾小球肾炎病例。首例患者表现为肾病综合征且肾功能正常，而第二例患者则患有复发性急性肾衰竭，同时肾小球毛细血管内存在独特的IgM沉积模式。我们对文献的回顾表明，这种关联虽然罕见，但已有足够多的病例记载，表明其并非偶然。与霍奇金病相关的最常见肾脏病变是微小病变病，而在NHL患者中则发现了更严重的肾小球病变。这反映在后一组患者中肾衰竭的发生率更高。尽管在已报道的病例中很少有长期随访，但已证明淋巴瘤的治疗可导致肾脏疾病得到改善甚至治愈。
