以多发性神经病为首发表现的威尔逊病。
Wilson disease with an initial manifestation of polyneuropathy.
作者信息
Jung Keun-Hwa, Ahn Tae-Beom, Jeon Beom S
机构信息
Department of Neurology and Clinical Research Institute, Seoul National University Hospital, Kyung Hee University Hospital, Seoul, South Korea.
出版信息
Arch Neurol. 2005 Oct;62(10):1628-31. doi: 10.1001/archneur.62.10.1628.
BACKGROUND
Recognition of Wilson disease (WD) is sometimes difficult because of its diverse manifestations. Peripheral neuropathy is rarely reported in the context of WD.
OBJECTIVE
To report an unusual patient with WD whose initial manifestation was peripheral neuropathy.
DESIGN
Case report.
SETTING
Neurology department in a tertiary referral center.
METHOD
Personal observation.
RESULT
A 17-year-old man, who was eventually diagnosed with WD, was initially seen with polyneuropathy at least 6 months prior to developing more typical symptoms of WD. Electrophysiological and pathological studies suggested a neuropathy of mixed type. Treatment for WD resulted in clinical and electrophysiological improvement.
CONCLUSION
Wilson disease may initially appear as a treatable polyneuropathy.
背景
由于威尔逊病（WD）表现多样，其识别有时较为困难。WD患者出现周围神经病变的情况鲜有报道。
目的
报告1例以周围神经病变为首发表现的罕见WD患者。
设计
病例报告。
单位
某三级转诊中心的神经内科。
方法
个人观察。
结果
一名最终被诊断为WD的17岁男性，在出现更典型的WD症状至少6个月前，最初表现为多发性神经病变。电生理和病理研究提示为混合型神经病变。WD治疗后临床及电生理表现均有改善。
结论
威尔逊病最初可能表现为可治疗的多发性神经病变。
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