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A multifunctional enzyme adds to its repertoire.一种多功能酶增添了其功能种类。
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A single residue in a novel ADP-ribosyl cyclase controls production of the calcium-mobilizing messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate.一种新型 ADP-ribosyl 环化酶中的单个残基控制着钙动员信使环 ADP-ribose 和烟酰胺腺嘌呤二核苷酸磷酸的产生。
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NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases.由ADP - 核糖基环化酶从环ADP - 核糖磷酸（cADPRP）和烟酸合成NAADP+ 。
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Cyclic ADP-ribose analogues containing the methylenebisphosphonate linkage: effect of pyrophosphate modifications on Ca2+ release activity.含有亚甲基双膦酸酯键的环状ADP-核糖类似物：焦磷酸修饰对Ca2+释放活性的影响。
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The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain.来自小鼠脑突触体的不依赖CD38的ADP核糖基环化酶：新生和成年大脑的比较研究
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Regulation of calcium signalling by adenine-based second messengers.腺嘌呤类第二信使对钙信号的调控
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ADP-ribosyl cyclase and GDP-ribosyl cyclase activities are not always equivalent: impact on the study of the physiological role of cyclic ADP-ribose.ADP-核糖基环化酶和GDP-核糖基环化酶的活性并不总是等同的：对环ADP-核糖生理作用研究的影响。
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Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system.环磷酸腺苷核糖作为神经系统中的一种通用钙信号分子。
Neurochem Int. 2007 Jul-Sep;51(2-4):192-9. doi: 10.1016/j.neuint.2007.06.023. Epub 2007 Jun 28.

引用本文的文献

1
Diadenosine homodinucleotide products of ADP-ribosyl cyclases behave as modulators of the purinergic receptor P2X7.二腺苷酰环化酶寡核苷酸产物作为嘌呤能受体 P2X7 的调节剂。
J Biol Chem. 2010 Jul 2;285(27):21165-74. doi: 10.1074/jbc.M109.097964. Epub 2010 May 3.

本文引用的文献

1
ADP-ribosyl cyclases generate two unusual adenine homodinucleotides with cytotoxic activity on mammalian cells.ADP-核糖基环化酶可生成两种对哺乳动物细胞具有细胞毒性活性的特殊腺嘌呤同型二核苷酸。
Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14509-14. doi: 10.1073/pnas.0503691102. Epub 2005 Sep 19.
2
Structure and enzymology of ADP-ribosyl cyclases: conserved enzymes that produce multiple calcium mobilizing metabolites.ADP-核糖基环化酶的结构与酶学：产生多种钙动员代谢产物的保守酶类
Curr Mol Med. 2004 May;4(3):249-61. doi: 10.2174/1566524043360708.
3
Multiplicity of Ca2+ messengers and Ca2+ stores: a perspective from cyclic ADP-ribose and NAADP.钙离子信使与钙离子储存的多样性：从环二磷酸腺苷核糖和烟酰胺腺嘌呤二核苷酸磷酸的角度来看
Curr Mol Med. 2004 May;4(3):227-37. doi: 10.2174/1566524043360753.
4
Evidence for an intracellular ADP-ribosyl cyclase/NAD+-glycohydrolase in brain from CD38-deficient mice.来自CD38基因敲除小鼠大脑中细胞内ADP-核糖基环化酶/NAD+糖水解酶的证据。
J Biol Chem. 2003 Oct 17;278(42):40670-8. doi: 10.1074/jbc.M301196200. Epub 2003 Aug 8.
5
ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology.Nudix基序同源性揭示钙通透性LTRPC2通道的ADP核糖门控
Nature. 2001 May 31;411(6837):595-9. doi: 10.1038/35079100.
6
Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers.环磷酸腺苷核糖（cADPR）和烟酰胺腺嘌呤二核苷酸磷酸（NAADP）作为钙信使的生理功能。
Annu Rev Pharmacol Toxicol. 2001;41:317-45. doi: 10.1146/annurev.pharmtox.41.1.317.
7
Dinucleotides as growth-promoting extracellular mediators. Presence of dinucleoside diphosphates Ap2A, Ap2G, and Gp2G in releasable granules of platelets.二核苷酸作为促进生长的细胞外介质。血小板可释放颗粒中存在二核苷二磷酸Ap2A、Ap2G和Gp2G。
J Biol Chem. 2001 Mar 23;276(12):8904-9. doi: 10.1074/jbc.M009527200. Epub 2000 Dec 13.
8
Dinucleoside polyphosphates-friend or foe?二核苷多磷酸——是友还是敌？
Pharmacol Ther. 2000 Aug-Sep;87(2-3):73-89. doi: 10.1016/s0163-7258(00)00041-3.
9
Enzymatic functions and structures of CD38 and homologs.CD38及其同源物的酶功能与结构
Chem Immunol. 2000;75:39-59. doi: 10.1159/000058774.
10
Extracellular cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors.细胞外环二磷酸腺苷核糖可增加细胞内游离钙浓度，并刺激人类造血祖细胞的增殖。
FASEB J. 2000 Apr;14(5):680-90. doi: 10.1096/fasebj.14.5.680.

A multifunctional enzyme adds to its repertoire.

作者信息

Walseth Timothy F

机构信息

Department of Pharmacology, University of Minnesota Medical School, 6-120 Jackson Hall, 321 Church Street Southeast, Minneapolis, MN 55455, USA.

出版信息

Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):14941-2. doi: 10.1073/pnas.0507258102. Epub 2005 Oct 10.

DOI:10.1073/pnas.0507258102
PMID:16217035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1257722/
Abstract
摘要