感染后急性小脑性共济失调中的自身抗体。

Autoantibodies in postinfectious acute cerebellar ataxia.

作者信息

Uchibori Ayumi, Sakuta Manabu, Kusunoki Susumu, Chiba Atsuro

机构信息

Department of Neurology, School of Medicine, Kyorin University, Mitaka, Tokyo 181-8611, Japan.

出版信息

Neurology. 2005 Oct 11;65(7):1114-6. doi: 10.1212/01.wnl.0000178802.38268.1e.

DOI:10.1212/01.wnl.0000178802.38268.1e

PMID:16217070

Abstract

The authors found serum immunoglobulin M (IgM) autoantibody in a patient with typical acute cerebellar ataxia (ACA) and identified the antigen molecule as triosephosphate isomerase (TPI). TPI antigenicity to the patient's antibody was the highest in the cerebellar tissue. Eight of 23 patients with ACA had increased IgM anti-TPI antibody titers vs those of healthy controls. Preceding Epstein-Barr virus infection was confirmed serologically in all 8 patients. Anti-TPI antibody decreased with clinical improvement.

摘要

作者在一名典型急性小脑性共济失调（ACA）患者中发现血清免疫球蛋白M（IgM）自身抗体，并确定抗原分子为磷酸丙糖异构酶（TPI）。TPI对该患者抗体的抗原性在小脑组织中最高。23例ACA患者中有8例IgM抗TPI抗体滴度高于健康对照。所有8例患者血清学检查均证实有EB病毒感染史。抗TPI抗体随临床症状改善而下降。