Mendlewicz J, Linkowski P, Van Cauter E
J Affect Disord. 1979 Mar;1(1):25-32. doi: 10.1016/0165-0327(79)90022-3.
There is mounting evidence showing that some pituitary and hypothalamic hormones play an important role in the affective disorders and may directly affect brain function and behavior. This report briefly reviews some recent endocrinological studies in affective illness with special reference to bipolar and unipolar form of illness. Data on prolactin and growth hormone response to levodopa in bipolar and unipolar illness presented. Preliminary data on plasma dopamine beta hydroxylase activity measured over a 24-h period are illustrated in patients suffering from bipolar and unipolar illnesses as compared to controls. The significance of these results is discussed in relation to biogenic amine dysfunction in the major affective disorders.
越来越多的证据表明，一些垂体和下丘脑激素在情感障碍中起重要作用，可能直接影响脑功能和行为。本报告简要回顾了近期关于情感性疾病的一些内分泌学研究，特别提及双相和单相情感性疾病。给出了双相和单相情感性疾病中催乳素和生长激素对左旋多巴反应的数据。与对照组相比，展示了双相和单相情感性疾病患者在24小时内测量的血浆多巴胺β羟化酶活性的初步数据，并讨论了这些结果在主要情感障碍中生物胺功能障碍方面的意义。
