Linkowski P, Brauman H, Mendlewicz J
Psychiatry Res. 1980 Dec;3(3):265-71. doi: 10.1016/0165-1781(80)90056-6.
Plasma prolactin levels and prolactin response to thyrotropin releasing hormone (TRH) were studied in 27 unipolar and 24 bipolar depressive female patients before and after tricyclic antidepressant treatment, as well as in 38 normal controls matched for age, sex, and menopausal status. Before antidepressant treatment, basal prolactin levels were significantly lower in both premenopausal and postmenopausal bipolar patients but only in postmenopausal unipolar patients when compared to controls. The prolactin response to TRH was significantly blunted in both unipolar and bipolar postmenopausal subjects but remained normal in all premenopausal (unipolar and bipolar) patients. These data suggest that prolactin pituitary function could be useful in the neuroendocrine study of depressive illness.
对27名单相抑郁女性患者、24名双相抑郁女性患者在三环类抗抑郁药治疗前后，以及38名年龄、性别和绝经状态相匹配的正常对照者，研究了血浆催乳素水平及催乳素对促甲状腺激素释放激素（TRH）的反应。在抗抑郁药治疗前，与对照组相比，绝经前和绝经后双相患者的基础催乳素水平均显著降低，但仅绝经后单相患者如此。绝经后单相和双相受试者对TRH的催乳素反应均显著减弱，但所有绝经前（单相和双相）患者的反应仍正常。这些数据表明，催乳素垂体功能在抑郁症的神经内分泌研究中可能有用。
