Festini Filippo, Beneventi Raffaella, Vignoli Noemi, Allegretti Nicoletta, Rontini Isabella, Campigatto Elena, Grondoni Gilda, Sanasi Silvia, Bongini Gianna
Nucleo Operativo per la Ri- cerca Infermieristica, Azienda Ospedaliero-Universitaria Meyer, via L.Giordono 13, 50132 Firenze.
Assist Inferm Ric. 2005 Apr-Jun;24(2):91-6.
Antibiotic intravenous (IV) therapy is of paramount importance in the treatment of cystic fibrosis (CF) lung disease. During their life CF patients have to undergo frequent IV antibiotic treatments. Peripheral venous catheters (PVC) -or cannulas- are often used to reduce the number of venepunctures needed to complete a treatment cycle, as well as to provide patients the best possible level of autonomy. The clinical experience in managing IV therapy in CF patients at Meyer Hospital in Florence, suggested that the in situ duration of PVCs varies greatly.
To understand which factors influence the duration of PVCs used to administer IVantibiotic in people with CF.
Cohort prospective study, integrated with retrospective data retrieval. MATERIALS, PATIENTS AND METHODS: We observed all the PVCs inserted during an 8-month period to CF patients followed at the CF Centre of Tuscany (Florence, Italy).
We studied 87 PVCs inserted to 36 patients in 56 IV antibiotic treatment cycles. The mean duration of PVCs was 8.3 days. The mean duration of PVCs used for 3 daily antibiotic administrations was longer than that of PVCs used for 2 daily antibiotic administrations (10.3 days vs. 6.5 days, p=0.001). Moreover, PVCs with a larger gauge (G22) had longer mean duration than smaller (G24) PVCs (9.6 days vs. 7.2 days, p=0.03). No statistically significant association was found between PVCs' duration and, respectively, the place where the treatment was administered (in hospital or at home), the arm used (dominant or non-dominant), the PVC's brand, patient's clinical condition and the concurrent use of either steroidal antinflammatory drugs or NSAIDs per os.
抗生素静脉注射疗法在囊性纤维化（CF）肺部疾病的治疗中至关重要。CF患者在其一生中必须频繁接受静脉抗生素治疗。外周静脉导管（PVC）——或套管——常被用于减少完成一个治疗周期所需的静脉穿刺次数，同时为患者提供尽可能高的自主程度。佛罗伦萨迈耶医院管理CF患者静脉治疗的临床经验表明，PVC的原位留置时间差异很大。
了解哪些因素会影响CF患者用于静脉注射抗生素的PVC的留置时间。
队列前瞻性研究，结合回顾性数据检索。
材料、患者与方法：我们观察了在8个月期间为意大利托斯卡纳（佛罗伦萨）CF中心随访的CF患者插入的所有PVC。
我们研究了在56个静脉抗生素治疗周期中为36名患者插入的87根PVC。PVC的平均留置时间为8.3天。用于每日3次抗生素给药的PVC的平均留置时间长于用于每日2次抗生素给药的PVC（10.3天对6.5天，p = 0.001）。此外，较大规格（G22）的PVC的平均留置时间比较小规格（G24）的PVC长（9.6天对7.2天，p = 0.03）。未发现PVC留置时间与治疗给药地点（住院或在家）、使用的手臂（优势臂或非优势臂）、PVC品牌、患者临床状况以及口服甾体类抗炎药或非甾体抗炎药的同时使用之间存在统计学上的显著关联。
