内源性抑郁症患者血浆中游离色氨酸及总色氨酸水平
Free and total plasma tryptophan in endogenous depression.
作者信息
Møller S E, Kirk L, Honoré P
出版信息
J Affect Disord. 1979 Mar;1(1):69-76. doi: 10.1016/0165-0327(79)90026-0.
The free and total plasma tryptophan concentrations were measured in 41 female depressive. Fifteen patients were subsequently treated with L-tryptophan. The free and total tryptophan were normal in the drug-free depressives and in the depressives on lithium. No significant in free and total plasma tryptophan were found between unipolar and bipolar depressed subjects, or between patients who recovered from depression following L-tryptophan therapy and patients who were resistant. The results suggest that the basal free tryptophan concentration in the plasma of depressed subjects is normal. They furthermore indicate that neither free nor total plasma tryptophan concentrations are valid predictors for the course of a treatment of depressed subjects with L-tryptophan.
对41名女性抑郁症患者的游离及总血浆色氨酸浓度进行了测量。随后，15名患者接受了L-色氨酸治疗。未服用药物的抑郁症患者及服用锂盐的抑郁症患者的游离和总色氨酸水平均正常。在单相抑郁和双相抑郁受试者之间，或在接受L-色氨酸治疗后康复的患者与耐药患者之间，游离和总血浆色氨酸均未发现显著差异。结果表明，抑郁症患者血浆中基础游离色氨酸浓度正常。此外，这些结果还表明，游离或总血浆色氨酸浓度均不能有效预测抑郁症患者接受L-色氨酸治疗的疗程。
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