用锂盐治疗的近期躁狂症患者的色氨酸耗竭
Tryptophan depletion in recently manic patients treated with lithium.
作者信息
Cassidy F, Murry E, Carroll B J
机构信息
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.
出版信息
Biol Psychiatry. 1998 Feb 1;43(3):230-2. doi: 10.1016/S0006-3223(97)00010-3.
BACKGROUND
Serotonin has been repeatedly implicated in the mechanism of action of lithium against acute mania. Its role, however, has never been directly confirmed.
METHODS
We studied recently manic patients successfully treated with lithium using a tryptophan depletion methodology.
RESULTS
Patients remained euthymic despite a confirmed decrease in serum tryptophan levels.
CONCLUSIONS
These data do not suggest that serotonin plays a critical role in the acute antimanic effect of lithium.
背景
血清素一直被反复认为与锂治疗急性躁狂的作用机制有关。然而，其作用从未得到直接证实。
方法
我们使用色氨酸耗竭法对近期成功接受锂治疗的躁狂患者进行了研究。
结果
尽管血清色氨酸水平确实下降，但患者仍保持心境正常。
结论
这些数据并不表明血清素在锂的急性抗躁狂作用中起关键作用。
Zotero 插件