Kamzolova S G, Sorokin A A, Dzhelyadin T D, Beskaravainy P M, Osypov A A
Institute of Cell Biophysics of RAS, Pushchino, Moscow region 142290, Russia.
J Biomol Struct Dyn. 2005 Dec;23(3):341-5.
Distribution of electrostatic potential of the complete sequence of E. coli genome was calculated. Comparative analysis of electrostatic patterns for 359 promoter and nonpromoter nucleotide sequences was carried out. It is found that nonpromoter regions are characterized by more homogeneous distribution of electrostatic potential with no common specific elements. Electrostatic patterns of promoter DNAs can be specified due to the presence of some distinctive motifs which may be involved as promoter signal elements in RNA-polymerase-promoter recognition.
计算了大肠杆菌基因组完整序列的静电势分布。对359个启动子和非启动子核苷酸序列的静电模式进行了比较分析。发现非启动子区域的特征是静电势分布更均匀，没有共同的特定元件。由于存在一些独特的基序，启动子DNA的静电模式可以被明确，这些基序可能作为启动子信号元件参与RNA聚合酶与启动子的识别。
