Thoms Sven, Erdmann Ralf
Ruhr-University-Bochum, Medical Faculty, Institute of Physiological Chemistry, Bochum, Germany.
FEBS J. 2005 Oct;272(20):5169-81. doi: 10.1111/j.1742-4658.2005.04939.x.
The abundance and size of cellular organelles vary depending on the cell type and metabolic needs. Peroxisomes constitute a class of cellular organelles renowned for their ability to adapt to cellular and environmental conditions. Together with transcriptional regulators, two groups of peroxisomal proteins have a pronounced influence on peroxisome size and abundance. Pex11-type peroxisome proliferators are involved in the proliferation of peroxisomes, defined here as an increase in size and/or number of peroxisomes. Dynamin-related proteins have recently been suggested to be required for the scission of peroxisomal membranes. This review surveys the function of Pex11-type peroxisome proliferators and dynamin-related proteins in peroxisomal proliferation and division.
细胞器的数量和大小因细胞类型和代谢需求而异。过氧化物酶体是一类以能够适应细胞和环境条件而闻名的细胞器。与转录调节因子一起，两组过氧化物酶体蛋白对过氧化物酶体的大小和数量有显著影响。Pex11型过氧化物酶体增殖剂参与过氧化物酶体的增殖，这里将其定义为过氧化物酶体大小和/或数量的增加。最近有人提出，动力蛋白相关蛋白是过氧化物酶体膜分裂所必需的。本文综述了Pex11型过氧化物酶体增殖剂和动力蛋白相关蛋白在过氧化物酶体增殖和分裂中的作用。
