Wei Daoyan, Kanai Masashi, Huang Suyun, Xie Keping
Department of Gastrointestinal Medical Oncology, Department of Neurosurgery and Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Carcinogenesis. 2006 Jan;27(1):23-31. doi: 10.1093/carcin/bgi243. Epub 2005 Oct 11.
Recent analyses revealed that Krüppel-like factors (KLFs) play important roles in both normal development and carcinogenesis. Of the 16 known KLFs, KLF4 has been shown to be involved in the regulation of proliferation, differentiation and tumorigenesis of gastrointestinal tract epithelium. Clinical, experimental and mechanistic findings indicate that KLF4 is a bona fide tumor suppressor for both gastric and colorectal cancers. In this review, we summarize how this growing area of research has formed and the challenging new frontiers for better understanding of the oncogenic potential of the KLFs.
最近的分析表明，Krüppel样因子（KLFs）在正常发育和致癌过程中都发挥着重要作用。在已知的16种KLFs中，KLF4已被证明参与胃肠道上皮细胞的增殖、分化和肿瘤发生的调控。临床、实验和机制研究结果表明，KLF4是胃癌和结直肠癌真正的肿瘤抑制因子。在这篇综述中，我们总结了这一不断发展的研究领域是如何形成的，以及在更好地理解KLFs致癌潜力方面面临的具有挑战性的新前沿。
