Lü Shuang-Hong, Yang Yi, Liu Shao-Jun
Institute of Basic Medical Sciences, Academy of Military Medical Science, Beijing 100850, China.
Sheng Li Xue Bao. 2005 Oct 25;57(5):552-6.
Neuronal PC12 cells induced by nerve growth factor (NGF) have been considered to be postmitotic and lack the ability to divide. However, in this study, we not only detected DNA synthesis but also observed cell division in some morphologically differentiated neuronal PC12 cells bearing long neurites. More interestingly, in addition to the division of perikaryon, the neurites located on the division site of the cell membrane also divided into two parts and were allocated to the two daughter cells. These results demonstrate that the morphologically differentiated neuronal PC12 cells still retain the ability to divide. This is the first report that neuronal PC12 cells as well as their neurites can divide.
由神经生长因子（NGF）诱导的神经元PC12细胞一直被认为是处于有丝分裂后期且缺乏分裂能力。然而，在本研究中，我们不仅检测到了DNA合成，还在一些具有长神经突的形态学分化神经元PC12细胞中观察到了细胞分裂。更有趣的是，除了胞核分裂外，位于细胞膜分裂部位的神经突也分裂成两部分并分配到两个子细胞中。这些结果表明，形态学分化的神经元PC12细胞仍然保留分裂能力。这是关于神经元PC12细胞及其神经突能够分裂的首次报道。
