Denolle T, Eon Y, Le Néel H, Seignard H, Battini J
Hôpital Dinard et Biotrial Rennes.
Arch Mal Coeur Vaiss. 2005 Jul-Aug;98(7-8):761-6.
To try to improve the cardiovascular risk of resistant hypertensive patients in general medicine in Brittany after using french hypertension recommendations.
581 hypertensive patients under 3 antihypertensive drugs have asked for an exoneration of the patients' social contribution: 297 (51%) were uncontrolled at their general practitioner (GP) among whom 106 (36%) have refused to take part in the program. 191 resistant hypertensive patients followed by 170 different GP have been pre-included. After a meeting between the social security physician, the GP measured blood pressure (BP) with a validated BP device and passed it on to the patient for a self-BP measurement (SBPM). In the case of a confirmed resistance, after specialist opinion, the treatment was then modified and the patient was checked after four months by his GP for a new clinical and self BP measurement.
After the initial automated BP measurement by GP, 51 patients (27%) had in fact controlled hypertension. Out of 136 resistant hypertensive patients (mean: 63 ys) during consultation (60% with systolic isolated hypertension), 121 (89%) have been closely followed during the whole study period among who 114 were also resistant with SBPM (94%). Only 8 patients (6%) were controlled at home. A check-up with specialist opinion was conducted: ECG (82%), echocardiography (59%), vascular echography (35%), funduscopy (30%), plasma renin/aldosterone measurement (15%), renal artery exploration (26%). Eight (7%) secondary hypertension have been founded. After 4 months, 32 (26%) obtained controlled hypertension during GP consultation and 15% during SBPM but the 20/32 controlled patients (62%) had a masked hypertension. Cholesterol levels (63% of dyslipidemics) and the body mass index (80% of overweighed patients) have not varied. On the contrary, 12/28 (48%) has stopped smoking. The coronary risk using Anderson's model has only decreased from 16.5% to 13.8%.
If this health program has shown its feasibility and the good participation of the GPs, treatment of hypertension and others risk factors really remains insufficient. On the contrary, the use of a validated automatic BP device has been really well carried out. Its use has allowed reclassifying as controlled one third of the resistant hypertensive patients and as uncontrolled at home one patient out of two which were controlled with GP. These results prove the necessity to increase this BP measurement technique in this population.
在遵循法国高血压治疗建议后,试图改善布列塔尼地区普通内科中难治性高血压患者的心血管疾病风险。
581名服用三种以上降压药的高血压患者申请免除社会贡献:其中297名(51%)在全科医生(GP)处血压未得到控制,其中106名(36%)拒绝参与该项目。191名由170名不同全科医生随访的难治性高血压患者被预先纳入。在社保医生会诊后,全科医生使用经过验证的血压测量设备测量血压,并将结果告知患者进行自我血压测量(SBPM)。在确诊为顽固性高血压的情况下,经专家会诊后调整治疗方案,4个月后由患者的全科医生再次检查,进行新的临床和自我血压测量。
在全科医生最初进行自动血压测量后,51名患者(27%)实际上血压得到了控制。在136名会诊时的难治性高血压患者(平均年龄63岁)中(60%为单纯收缩期高血压),121名(89%)在整个研究期间得到密切随访,其中114名患者自我血压测量时仍为顽固性高血压(94%)。只有8名患者(6%)在家中血压得到控制。进行了专家会诊检查:心电图(82%)、超声心动图(59%)、血管超声(35%)、眼底检查(30%)、血浆肾素/醛固酮测定(15%)、肾动脉探查(26%)。发现8例(7%)继发性高血压。4个月后,32名患者(26%)在全科医生会诊时血压得到控制,自我血压测量时为15%,但这32名血压得到控制的患者中有20名(62%)存在隐匿性高血压。胆固醇水平(63%的血脂异常患者)和体重指数(80%的超重患者)没有变化。相反,28名患者中有12名(48%)戒烟。使用安德森模型计算的冠心病风险仅从16.5%降至13.8%。
尽管该健康项目已证明其可行性以及全科医生的良好参与度,但高血压及其他危险因素的治疗仍显不足。相反,经过验证的自动血压测量设备的使用执行得很好。其使用使三分之一的难治性高血压患者重新分类为血压得到控制,并且使在全科医生处血压得到控制的患者中有一半在家中血压未得到控制。这些结果证明有必要在该人群中增加这种血压测量技术的应用。