一种避免使用预先形成的金属化亲核试剂的新型催化共轭加成/羟醛缩合策略。
A new catalytic conjugate addition/aldol strategy that avoids preformed metalated nucleophiles.
作者信息
Subburaj Kandasamy, Montgomery John
机构信息
Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.
出版信息
J Am Chem Soc. 2003 Sep 17;125(37):11210-1. doi: 10.1021/ja0362048.
PMID:16220938
Abstract
A new conjugate addition/aldol strategy has been developed. Unlike conventional procedures that require metalation of the nucleophilic species, the procedure allows the direct coupling of aryl iodides, aldehydes, and acrylates in a nickel-catalyzed, organozinc-promoted process.
摘要
一种新的共轭加成/羟醛缩合策略已经被开发出来。与需要对亲核物种进行金属化的传统方法不同，该方法允许在镍催化、有机锌促进的过程中，使芳基碘化物、醛和丙烯酸酯直接偶联。
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