使用有机锌试剂的无铜直接多米诺共轭加成-环烯丙基化反应
Direct Copper-Free Domino Conjugate Addition-Cycloallylation using Organozinc Reagents.
作者信息
Komanduri Venukrishnan, Pedraza Fernando, Krische Michael J
机构信息
University of Texas at Austin, Department of Chemistry and Biochemistry, 1 University Station - A5300, Austin, TX 78712-1167, USA.
出版信息
Adv Synth Catal. 2008 Jul 7;350(10):1569-1576. doi: 10.1002/adsc.200800242.
The Direct Approach: Enones possessing appendant allylic carbonates react directly with diorganozinc reagents in the presence of zinc diiodide [ZnI(2)] to provide 5- and 6-membered ring products of tandem or domino conjugate addition-cycloallylation in good to excellent yield. In a related copper-free transformation, allylic carbonates are found to engage in direct allylic substitution with diorganozinc reagents.
直接方法
带有烯丙基碳酸酯侧基的烯酮在二碘化锌[ZnI₂]存在下与二有机锌试剂直接反应，以良好至优异的产率提供串联或多米诺共轭加成-环烯丙基化的5元和6元环产物。在一个相关的无铜转化反应中，发现烯丙基碳酸酯与二有机锌试剂发生直接烯丙基取代反应。
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