Coronnello Marcella, Mini Enrico, Caciagli Barbara, Cinellu Maria Agostina, Bindoli Alberto, Gabbiani Chiara, Messori Luigi
Department of Pharmacology and Chemistry, University of Florence, Florence, Italy, Department of Chemistry, University of Sassari, Sassari, Italy.
J Med Chem. 2005 Oct 20;48(21):6761-5. doi: 10.1021/jm050493o.
The effects of a few cytotoxic organogold(III) compounds on ovarian A2780 human cancer cells were investigated in comparison to cisplatin and oxaliplatin. The tested compounds produced significant antiproliferative effects and promoted apoptosis to a greater extent than platinum drugs while causing only modest cell cycle modifications. The mechanistic implications of these findings are discussed: mitochondrial pathways are proposed to be directly involved in the apoptotic process in relation to selective inhibition of thioredoxin reductase.
与顺铂和奥沙利铂相比，研究了几种细胞毒性有机金（III）化合物对人卵巢癌A2780细胞的影响。所测试的化合物产生了显著的抗增殖作用，比铂类药物更能促进细胞凋亡，同时仅引起适度的细胞周期改变。讨论了这些发现的机制意义：提出线粒体途径与硫氧还蛋白还原酶的选择性抑制有关，直接参与凋亡过程。
