Fraser Michelle L, Lee Andy H, Binns Colin W
Curtin University of Technology, School of Public Health, GPO Box U 1987, Perth WA 6845, Australia.
Expert Rev Anticancer Ther. 2005 Oct;5(5):847-54. doi: 10.1586/14737140.5.5.847.
Prostate cancer has the third highest incidence of all cancers in men worldwide and is the most common neoplasm diagnosed among men beyond middle age in many developed countries. Mounting evidence surrounding the consumption of tomato products has shown promise for the prevention of prostate cancer. This protective effect has more recently been linked to lycopene, the most abundant carotenoid in tomatoes. Lycopene is a natural pigment that gives the red color to many foods. In Western countries, 85% of dietary lycopene can be attributed to the consumption of tomato-based products. This article reviews emerging evidence from epidemiologic studies for the role of lycopene in prostate cancer prevention. The majority of evidence currently comes from observational studies, but recent human clinical trials and animal studies have provided additional support. Growing evidence on the biologic mechanisms of lycopene in prostate cancer prevention also confirm the epidemiologic findings.
前列腺癌是全球男性所有癌症中发病率第三高的癌症，并且在许多发达国家，它是中年以上男性中最常被诊断出的肿瘤。越来越多关于食用番茄制品的证据表明其在预防前列腺癌方面具有前景。这种保护作用最近与番茄红素联系在一起——番茄红素是番茄中含量最丰富的类胡萝卜素。番茄红素是一种天然色素，赋予许多食物红色。在西方国家，85%的膳食番茄红素来源于食用以番茄为基础的产品。本文综述了流行病学研究中关于番茄红素在预防前列腺癌方面作用的新证据。目前大多数证据来自观察性研究，但最近的人体临床试验和动物研究提供了更多支持。关于番茄红素预防前列腺癌生物学机制的证据不断增加，也证实了流行病学研究结果。
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