Chopra Hitesh, Bibi Shabana, Goyal Rajat, Gautam Rupesh K, Trivedi Rashmi, Upadhyay Tarun Kumar, Mujahid Mohd Hasan, Shah Mohammad Ajmal, Haris Muhammad, Khot Kartik Bhairu, Gopan Gopika, Singh Inderbir, Kim Jin Kyu, Jose Jobin, Abdel-Daim Mohamed M, Alhumaydhi Fahad A, Emran Talha Bin, Kim Bonglee
Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Department of Biosciences, Shifa Tameer-e-milat University, Islamabad, Pakistan.
Front Oncol. 2022 Jul 12;12:925379. doi: 10.3389/fonc.2022.925379. eCollection 2022.
There are more than two hundred fifty different types of cancers, that are diagnosed around the world. Prostate cancer is one of the suspicious type of cancer spreading very fast around the world, it is reported that in 2018, 29430 patients died of prostate cancer in the United State of America (USA), and hence it is expected that one out of nine men diagnosed with this severe disease during their lives. Medical science has identified cancer at several stages and indicated genes mutations involved in the cancer cell progressions. Genetic implications have been studied extensively in cancer cell growth. So most efficacious drug for prostate cancer is highly required just like other severe diseases for men. So nutraceutical companies are playing major role to manage cancer disease by the recommendation of best natural products around the world, most of these natural products are isolated from plant and mushrooms because they contain several chemoprotective agents, which could reduce the chances of development of cancer and protect the cells for further progression. Some nutraceutical supplements might activate the cytotoxic chemotherapeutic effects by the mechanism of cell cycle arrest, cell differentiation procedures and changes in the redox states, but in other, it also elevate the levels of effectiveness of chemotherapeutic mechanism and in results, cancer cell becomes less reactive to chemotherapy. In this review, we have highlighted the prostate cancer and importance of nutraceuticals for the control and management of prostate cancer, and the significance of nutraceuticals to cancer patients during chemotherapy.
全球诊断出的癌症有250多种。前列腺癌是一种在全球迅速蔓延的可疑癌症类型，据报道，2018年，美国有29430名患者死于前列腺癌，预计九分之一的男性在其一生中会被诊断出患有这种严重疾病。医学已经确定了癌症的几个阶段，并指出了参与癌细胞进展的基因突变。基因影响在癌细胞生长中得到了广泛研究。因此，与男性的其他严重疾病一样，迫切需要治疗前列腺癌的最有效药物。因此，营养保健品公司通过推荐全球最佳天然产品在管理癌症疾病方面发挥着重要作用，这些天然产品大多从植物和蘑菇中提取，因为它们含有几种化学保护剂，可以减少患癌几率并保护细胞进一步发展。一些营养保健品补充剂可能通过细胞周期停滞、细胞分化程序和氧化还原状态变化的机制激活细胞毒性化疗作用，但另一方面，它也提高了化疗机制的有效性水平，结果癌细胞对化疗的反应性降低。在这篇综述中，我们强调了前列腺癌以及营养保健品对前列腺癌控制和管理的重要性，以及营养保健品对癌症患者化疗期间的意义。
