Chiu Susan S, Lau Yu-Lung
Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China.
Expert Rev Vaccines. 2005 Oct;4(5):629-43. doi: 10.1586/14760584.4.5.629.
Varicella zoster virus causes an acute infection that affects most children globally, but the age of infection can be greater in residents of tropical areas. It has generally been considered a mild disease, although there are accumulating data to show that it can cause significant morbidity and mortality in immunocompetent as well as immunocompromised children and adults. Oka-strain live attenuated varicella vaccines were developed in the 1970s. Varilrix developed by GlaxoSmithKline Biologicals (Rixensart, Belgium), is one of the vaccines produced and marketed in over 80 countries. Similar to the other Oka-strain vaccines, Varilrix is safe, immunogenic and efficacious in both immunocompromised and immunocompetent children and adults.
水痘带状疱疹病毒引起的急性感染影响全球大多数儿童，但热带地区居民的感染年龄可能更大。虽然水痘一般被认为是一种轻症疾病，但越来越多的数据表明，它在免疫功能正常以及免疫功能低下的儿童和成人中均可导致显著的发病率和死亡率。20世纪70年代研制出了Oka株减毒活水痘疫苗。葛兰素史克生物制品公司（比利时里克森萨特）生产的Varilrix是在80多个国家生产和销售的疫苗之一。与其他Oka株疫苗类似，Varilrix在免疫功能低下和免疫功能正常的儿童及成人中均安全、具有免疫原性且有效。
