Haas R J, Belohradsky B, Dickerhoff R, Eichinger K, Eife R, Holtmann H, Goetz O, Graubner U, Peller P
Postgrad Med J. 1985;61 Suppl 4:69-72.
Twenty-six patients with acute leukaemia and other malignancies susceptible to varicella were vaccinated with the Oka-strain live attenuated varicella vaccine during maintenance chemotherapy. All recipients showed no adverse clinical reactions. There was no spread of vaccine virus. Seroconversion was 94% in seronegative patients. Among those having low antibody titres before vaccination, a booster effect was demonstrable in 56%. None of the seroconverted recipients contracted varicella despite documented contact exposure. No case of herpes zoster occurred. The results suggest that, in immunocompromised children, live varicella vaccination has a protective effect against varicella infection which may result in a mortality rate of up to 7% in these patients.
26例患有急性白血病及其他易感染水痘的恶性肿瘤患者在维持化疗期间接种了Oka株减毒活水痘疫苗。所有接种者均未出现不良临床反应。疫苗病毒未发生传播。血清阴性患者的血清转化率为94%。在接种前抗体滴度较低的患者中，56%的患者显示出增强效应。所有血清转化的接种者尽管有明确的接触暴露史，但均未感染水痘。未发生带状疱疹病例。结果表明，在免疫功能低下的儿童中，接种活水痘疫苗对水痘感染具有保护作用，而水痘感染在这些患者中的死亡率可能高达7%。
