Collins William E, Galland G Gale, Barnwell John W, Udhayakumar Venkatachalam, Sullivan JoAnn S, Nace Douglas, Tongren Jon Eric, Williams Tyrone, Roberts Jacquelin, Shi Ya Ping, Lal Altaf A
Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, U. S. Department of Health and Human Services, Atlanta, Georgia 30341, USA.
Am J Trop Med Hyg. 2005 Oct;73(4):686-93.
A vaccine trial was conducted to determine the efficacy of a multicomponent candidate vaccine, FALVAC-1, against Plasmodium falciparum in Aotus nancymai monkeys. After two immunizations, animals were challenged intravenously with parasites of the Vietnam Oak Knoll (FVO) strain of P. falciparum. The primary outcome was to determine the protective response of the monkeys to immunization with the FALVAC-1 antigen produced in baculovirus when combined with different adjuvants (alum, QS-21, ASO2a, CRL1005/oil, and CRL1005/saline) as compared with FALVAC-1 with FCA/FIA and antigen alone. When compared with the monkeys immunized with FALVAC-1 alone, FALVAC-1 with FCA/FIA reduced the mean parasite count (to Day 11), reduced the mean accumulated parasitemia (through Day 11), and extended the number of days to treatment. None of the other 5 antigen-adjuvant combinations were able to provide discernable levels of protection based on log(parasitemia) and log(cumulative parasitemia) to Day 11.
进行了一项疫苗试验，以确定一种多组分候选疫苗FALVAC-1对南美白狨猴体内恶性疟原虫的疗效。两次免疫后，给动物静脉注射恶性疟原虫越南橡树岭（FVO）株的寄生虫。主要结果是确定与使用弗氏完全佐剂/不完全佐剂的FALVAC-1和单独抗原相比，当与不同佐剂（明矾、QS-21、ASO2a、CRL1005/油和CRL1005/盐水）联合使用时，用杆状病毒生产的FALVAC-1抗原免疫的猴子的保护反应。与单独用FALVAC-1免疫的猴子相比，使用弗氏完全佐剂/不完全佐剂的FALVAC-1降低了平均寄生虫计数（至第11天），降低了平均累积寄生虫血症（至第11天），并延长了至治疗的天数。基于第11天的对数（寄生虫血症）和对数（累积寄生虫血症），其他5种抗原-佐剂组合均无法提供可识别的保护水平。
