Hargreaves Garth A, McGregor Iain S, Sachdev Perminder S
School of Psychiatry, University of New South Wales, Sydney, 2052, Australia.
Psychiatry Res. 2005 Nov 15;137(1-2):113-21. doi: 10.1016/j.psychres.2005.07.008. Epub 2005 Oct 11.
Transcranial magnetic stimulation (TMS) has been proposed as a treatment for depression and anxiety disorders. While the antidepressant effect has been modelled in animals, there have been few attempts to examine a possible anxiolytic effect of repetitive TMS (rTMS) in animal models. We administered 18 days of rTMS to male Sprague-Dawley rats. On days 10 through 18, rats were tested in several anxiety models (social interaction, emergence, elevated plus-maze, and predator odor avoidance) and in the forced swim test. No group differences were apparent on any of the anxiety models, while TMS produced an antidepressant effect in the forced swim test. Interestingly, on day 1 of the forced swim test, the home cage control group displayed increased swimming behaviour compared with sham-treated animals, suggesting an observable level of stress may have accompanied sham treatment. The results from the forced swim test suggested that TMS had modest antidepressant properties, but it did not show anxiolytic properties in the models examined. The study also suggested that stress associated with handling should be taken into account in the interpretation of TMS studies in animals.
经颅磁刺激（TMS）已被提议作为治疗抑郁症和焦虑症的方法。虽然抗抑郁作用已在动物模型中得到模拟，但很少有人尝试在动物模型中研究重复经颅磁刺激（rTMS）可能的抗焦虑作用。我们对雄性Sprague-Dawley大鼠进行了18天的rTMS治疗。在第10天至第18天，对大鼠进行了多种焦虑模型（社交互动、新环境探索、高架十字迷宫和捕食者气味回避）以及强迫游泳试验。在任何焦虑模型中均未观察到组间差异，而TMS在强迫游泳试验中产生了抗抑郁作用。有趣的是，在强迫游泳试验的第1天，与假手术处理的动物相比，笼内对照组的游泳行为增加，这表明假手术处理可能伴随着可观察到的应激水平。强迫游泳试验的结果表明，TMS具有适度的抗抑郁特性，但在所检测的模型中未显示出抗焦虑特性。该研究还表明，在解释动物TMS研究结果时应考虑与处理相关的应激因素。
