Tsuzuki Hideaki, Takahashi Noboru, Kojima Akihiro, Narita Norihiko, Sunaga Hiroshi, Takabayashi Tetsuji, Fujieda Shigeharu
Department of Otorhinolaryngology-Head and Neck Surgery, University of Fukui, 23-3 Shimoaizuki, Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan.
Auris Nasus Larynx. 2006 Mar;33(1):37-42. doi: 10.1016/j.anl.2005.07.019. Epub 2005 Oct 11.
Tumor cell migration and metastasis have many similarities with leukocyte trafficking regulated by chemokines and their receptors. In this study, we investigated the expression of CC chemokine receptor 7 (CCR7) in oral and oropharyngeal squamous cell carcinomas (SCCs) using an immunohistochemical approach.
Among 90 cases of oral and oropharyngeal SCCs, 54 cases (60%) were positive for CCR7. The CCR7-positive group had a significantly lower incidence of being disease-free and an overall lower survival rate than the CCR7-negative group (p<0.01 and p<0.01, respectively). Among the 35 patients who died of cancer, 28 patients (80%) were positive for CCR7. The expression of CCR7 was significantly associated with five clinical factors. SCCs expressing CCR7 tend to have large, lymph node metastases, progressive stages, local recurrences and cancer death. The CCR7 expression of metastatic SCCs in draining lymph nodes was detected, and the staining score of CCR7 between primary SCCs and metastatic SCCs were significantly correlated (p<0.01).
The investigation of CCR7 expression in oral and oropharyngeal SCCs may be useful to predict patients prognoses.
肿瘤细胞的迁移和转移与趋化因子及其受体调控的白细胞运输有许多相似之处。在本研究中，我们采用免疫组织化学方法研究了CC趋化因子受体7（CCR7）在口腔和口咽鳞状细胞癌（SCC）中的表达情况。
在90例口腔和口咽SCC病例中，54例（60%）CCR7呈阳性。CCR7阳性组的无病发生率显著低于CCR7阴性组，总体生存率也更低（分别为p<0.01和p<0.01）。在35例死于癌症的患者中，28例（80%）CCR7呈阳性。CCR7的表达与五个临床因素显著相关。表达CCR7的SCC往往体积较大、有淋巴结转移、分期进展、局部复发且导致癌症死亡。检测了引流淋巴结中转移性SCC的CCR7表达情况，原发SCC和转移性SCC之间CCR7的染色评分显著相关（p<0.01）。
研究CCR7在口腔和口咽SCC中的表达情况可能有助于预测患者的预后。
