Foreman-Wykert Amy K, Miller Jeffery F
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095-1747, USA.
Trends Microbiol. 2005 Dec;13(12):559-60. doi: 10.1016/j.tim.2005.09.007. Epub 2005 Oct 11.
Bordetella pertussis is a strictly human pathogen. Experimental infection of other animals can occur with large inoculating doses; rat, mice and primate models have been used to study pathogenesis and immunity. Recently, it was shown that newborn piglets are susceptible to B. pertussis. Lung pathophysiology of infected piglets was similar to that of human infants that develop bronchopneumonia. Piglets and infants are anatomically similar and maternal antibodies are transferred and secreted by a similar mechanism. This model could be valuable for studying the roles of passively and actively acquired immunity against B. pertussis.
百日咳博德特氏菌是一种严格的人类病原体。使用大剂量接种时可使其他动物发生实验性感染；大鼠、小鼠和灵长类动物模型已被用于研究发病机制和免疫。最近发现，新生仔猪对百日咳博德特氏菌易感。感染仔猪的肺部病理生理学与发生支气管肺炎的人类婴儿相似。仔猪和婴儿在解剖学上相似，母体抗体通过相似的机制转移和分泌。该模型对于研究被动和主动获得性免疫在抵抗百日咳博德特氏菌中的作用可能具有重要价值。
