Laboratory of Pediatric Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
FEMS Microbiol Rev. 2011 May;35(3):441-74. doi: 10.1111/j.1574-6976.2010.00257.x. Epub 2011 Jan 5.
Pertussis, or whooping cough, is a highly contagious, acute respiratory disease of humans that is caused by the Gram-negative bacterial pathogen Bordetella pertussis. In the face of extensive global vaccination, this extremely monomorphic pathogen has persisted and re-emerged, causing approximately 300,000 deaths each year. In this review, we discuss the interaction of B. pertussis with the host mucosal epithelium and immune system. Using a large number of virulence factors, B. pertussis is able to create a niche for colonization in the human respiratory tract. The successful persistence of this pathogen is mainly due to its ability to interfere with almost every aspect of the immune system, from the inhibition of complement- and phagocyte-mediated killing to the suppression of T- and B-cell responses. Based on these insights, we delineate ideas for the rational design of improved vaccines that can target the 'weak spots' in the pathogenesis of this highly successful pathogen.
百日咳，又称“鸡咳”“鸬鹚咳”，是一种由革兰氏阴性细菌百日咳博德特氏菌引起的高传染性急性呼吸道疾病。尽管广泛接种疫苗，这种极其同形的病原体仍持续存在并再次出现，每年导致约 30 万人死亡。在这篇综述中，我们讨论了百日咳博德特氏菌与宿主黏膜上皮和免疫系统的相互作用。通过大量的毒力因子，百日咳博德特氏菌能够在人类呼吸道中创造一个定植的小生境。这种病原体的成功持续存在主要是由于它能够干扰免疫系统的几乎各个方面，从抑制补体和吞噬细胞介导的杀伤到抑制 T 细胞和 B 细胞的反应。基于这些见解，我们提出了合理设计改进型疫苗的思路，这些疫苗可以针对这种高度成功的病原体的发病机制中的“弱点”。
