实验性神经症期间红细胞生成的调节机制。

Mechanisms of regulation of erythropoiesis during experimental neuroses.

作者信息

Skurikhin E G, Dygai A M, Provalova N V, Minakova M Yu, Suslov N I

机构信息

Laboratory of Pathophysiology and Experimental Therapy, Group of Psychopharmacology, Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.

出版信息

Bull Exp Biol Med. 2005 May;139(5):543-9. doi: 10.1007/s10517-005-0341-z.

DOI:10.1007/s10517-005-0341-z

PMID:16224545

Abstract

We studied the mechanisms of erythropoiesis regulation in a conflict situation and during paradoxical sleep deprivation. Plastic reconstruction of the erythroid hemopoietic stem during experimental neuroses is regulated by a complex multicomponent and multilevel system. This system consists of central adrenergic structures, sympathetic part of the autonomic nervous system, and alpha- and beta-adrenoceptors on erythroid precursors and cells of the hemopoietic microenvironment. Erythroid cells receive instructive information from the central nervous system via adrenoceptors on cells of the hemopoiesis-inducing microenvironment and erythroid precursors. Hyperplasia (conflict situation) and suppression of erythropoiesis (paradoxical sleep deprivation) are associated with specificity of central adrenergic regulatory mechanisms.

摘要

我们研究了冲突情境和异相睡眠剥夺期间红细胞生成调节的机制。实验性神经症期间红系造血干细胞的可塑性重建受复杂的多组分和多层次系统调节。该系统由中枢肾上腺素能结构、自主神经系统的交感部分以及红系前体细胞和造血微环境细胞上的α和β肾上腺素能受体组成。红系细胞通过造血诱导微环境细胞和红系前体细胞上的肾上腺素能受体从中枢神经系统接收指导性信息。红细胞生成的增生（冲突情境）和抑制（异相睡眠剥夺）与中枢肾上腺素能调节机制的特异性有关。