Thy 1,2+细胞在实验性神经症期间造血调节中的作用。
Role of Thy 1,2+ cells in the regulation of hemopoiesis during experimental neuroses.
作者信息
Skurikhin E G, Pershina O V, Suslov N I, Dygai A M, Gol'dberg E D
机构信息
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia.
出版信息
Bull Exp Biol Med. 2005 Jun;139(6):643-6. doi: 10.1007/s10517-005-0366-3.
We studied the direct and stromal cell-mediated effects of bone marrow Thy 1,2+ cells on the growth of granulocyte-macrophage and erythroid colonies from the bone marrow of CBA/CaLac mice with experimental neuroses (conflict situation and paradoxical sleep deprivation). Proliferation and differentiation of hemopoietic precursors during neuroses are controlled by regulatory T cells. In conflict situation Thy 1,2+ cells stimulate the growth of hemopoietic precursors, which is associated with their direct effect and interaction with adherent cells of the hemopoiesis-inducing microenvironment. The interaction of Thy 1,2+ cells with adherent bone marrow cells during paradoxical sleep deprivation stimulates the formation of only granulocyte-macrophage colonies.
我们研究了骨髓Thy 1,2+细胞对患有实验性神经症（冲突情境和反常睡眠剥夺）的CBA/CaLac小鼠骨髓中粒细胞-巨噬细胞集落和红系集落生长的直接作用以及基质细胞介导的作用。神经症期间造血前体细胞的增殖和分化受调节性T细胞控制。在冲突情境中，Thy 1,2+细胞刺激造血前体细胞的生长，这与其直接作用以及与造血诱导微环境的黏附细胞相互作用有关。在反常睡眠剥夺期间，Thy 1,2+细胞与骨髓黏附细胞的相互作用仅刺激粒细胞-巨噬细胞集落的形成。
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