Pach Dorota, Urbanik Andrzej, Szczepańska Lucja, Hubalewska Alicja, Huszno Bohdan, Groszek Barbara, Jenner Bartosz
Department of Endocrinology, Jagiellonian University Medical College, Kraków, Poland.
Przegl Lek. 2005;62(6):441-5.
There were 10 acutely CO poisoned study patients without CNS history (head traumas, epilepsy, dementia, migraine or alcoholic diseases) in whom (99m)Tc-HmPAO SPET, HMRS and neuropsychological testing were performed. 99mTc-HmPAO SPET and neuropsychological testing were performed twice: in acute phase and at six months post CO exposure. HMRS was carried out at 8 months post CO exposure. A multidimensional analysis of variance (MANOVA) was used to statistical analysis. Regional CBF disturbances in acute phase of CO poisoning were observed in frontal cortex, basal ganglia and parietal cortex respectively. The most reversible, as seen in control (99m)Tc-HmPAO SPET examination, were the changes observed in parietal cortex. Diffuse generalized cortex hypoperfusion, both in acute phase and at 6 months post exposure, was seen only in one the patient. In all of the examined patients different elevation in mobile lipid or/and lactate concentration in frontal lobe or/and basal ganglia was revealed by HMRS evaluation at eight months post acute CO exposure. Results of neuropsychological testing at baseline and at 6 months partially correlated with neuro-imagine techniques applied.
有10名急性一氧化碳中毒的研究患者，无中枢神经系统病史（头部外伤、癫痫、痴呆、偏头痛或酒精性疾病），对其进行了（99m）Tc-HmPAO单光子发射计算机断层扫描（SPET）、磁共振波谱（HMRS）和神经心理学测试。（99m）Tc-HmPAO SPET和神经心理学测试进行了两次：在急性期和一氧化碳暴露后6个月。HMRS在一氧化碳暴露后8个月进行。采用多因素方差分析（MANOVA）进行统计学分析。一氧化碳中毒急性期分别在额叶皮质、基底神经节和顶叶皮质观察到局部脑血流紊乱。在对照（99m）Tc-HmPAO SPET检查中可见，顶叶皮质的变化最具可逆性。仅在1例患者中观察到急性期和暴露后6个月时弥漫性全皮质灌注不足。在急性一氧化碳暴露8个月后，通过HMRS评估发现，所有接受检查的患者额叶或/和基底神经节中移动脂质或/和乳酸浓度均有不同程度升高。基线和6个月时的神经心理学测试结果与应用的神经影像学技术部分相关。
