Kao C H, Hung D Z, ChangLai S P, Liao K K, Chieng P U
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
J Nucl Med. 1998 May;39(5):769-72.
Technetium-99m-hexamethylpropylene amine oxime (HMPAO) brain images with fanbeam SPECT, in combination with surface three-dimensional display, were used to detect basal ganglion and cerebral cortex anomalies in the acute phase of carbon monoxide (CO) poisoning.
Ten patients, aged 16-29 yr, with acute CO poisoning and no past history of neurologic disorders were enrolled in this study. After oxygen treatment, all 10 patients were investigated using 99mTc-HMPAO brain images with fanbeam SPECT and surface three-dimensional display. Meanwhile, 6 of 10 patients also received a brain CT scan.
CT scan findings were negative in all 6 patients. Fanbeam SPECT demonstrated unilateral or bilateral hypoactivity of basal ganglia in 6 patients. Local hypoactivity anomalies were found in the brain cortex of 7 patients, using surface three-dimensional display of the brain. Only 2 of 10 patients had normal 99mTc-HMPAO brain images.
This study suggests that, in comparison with traditional brain imaging techniques, 99mTc-HMPAO brain imaging with fanbeam SPECT in combination with surface three-dimensional display is a better tool for early detection of regional cerebral anomalies in acute CO poisoning.
使用扇束单光子发射计算机断层扫描（SPECT）的锝-99m-六甲基丙烯胺肟（HMPAO）脑显像，结合表面三维显示，用于检测一氧化碳（CO）中毒急性期的基底神经节和大脑皮质异常。
本研究纳入10例年龄在16 - 29岁之间、患有急性CO中毒且无神经系统疾病既往史的患者。经过氧疗后，所有10例患者均采用扇束SPECT的99mTc - HMPAO脑显像及表面三维显示进行检查。同时，10例患者中有6例还接受了脑部CT扫描。
所有6例患者的CT扫描结果均为阴性。扇束SPECT显示6例患者基底神经节单侧或双侧活性减低。通过大脑表面三维显示，发现7例患者大脑皮质存在局部活性减低异常。10例患者中仅有2例99mTc - HMPAO脑显像正常。
本研究表明，与传统脑成像技术相比，采用扇束SPECT的99mTc - HMPAO脑成像结合表面三维显示是早期检测急性CO中毒局部脑异常的更好工具。
