Chodorowski Zygmunt, Sein Anand Jacek, Madaliński Mariusz, Rutkowski Bolesław, Cylkowska Barbara, Rutkowski Przemysław, Wiśniewski Marek, Hajduk Adam
1st Clinic of Internal Diseases and Acute Poisonings, Medical University of Gdańsk, Poland.
Przegl Lek. 2005;62(6):468-70.
The enzymatic investigations were done in 56 patients, including 30 females and 26 males in the age range 18-76 (mean 52 +/- 12). Thirty two of them (57.1%) suffered from type 2 diabetes. All the patients consumed voluntarily Tricholoma equestre; 43 of them only once from 70 to 150 g, and 13 patients from two to four times for 4 consecutive days (between 300 g and 1200 g). Twenty seven patients, because of hyperlipidemia, took statins (simvastatin á 20 mg--15 patients, lovastatin á 20 mg--6 patients, fluvastatin á 80 mg--3 patients, atorvastatin á 20 mg--3 patients) and seven took fibrates (4 patients-- enofibrate á 267 mg, and 3 patients--ciprofibrate á 100 mg). Two subjects ingested both simvastatin á 20 mg and fenofibrate á 267 mg. Three to six days after the last mushroom dish, blood samples were taken from patients to examine the serum creatine kinase (CK), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities. The biochemical analyses were performed by means of the kinetic spectrophotometry using the autoanalyzer Architect ClI8200 with Abbott proprietary reagents. Statistical analysis was performed by means of t-Student test. Tricholoma equestre taken by patients in a total amount from 70 g to 1200 g for four consecutive days did not cause the significant increase in serum CK, AST, ALT activities. Similar mushroom dishes consumed by patients constantly using statins or fibrates also did not increase significantly the serum CK, AST, ALT activities. Patients treated with statins or fibrates may eat Tricholoma equestre in reasonable amount according to the established tradition.
对56例患者进行了酶学研究，其中包括30名女性和26名男性，年龄在18至76岁之间（平均52±12岁）。其中32例（57.1%）患有2型糖尿病。所有患者均自愿食用了黄绿蜜环菌；其中43例仅食用过一次，食用量为70至150克，13例连续4天食用了两至四次（食用量在300克至1200克之间）。27例患者因高脂血症服用了他汀类药物（辛伐他汀20毫克——15例患者，洛伐他汀20毫克——6例患者，氟伐他汀80毫克——3例患者，阿托伐他汀20毫克——3例患者），7例服用了贝特类药物（4例患者——非诺贝特267毫克，3例患者——环丙贝特100毫克）。两名受试者同时服用了辛伐他汀20毫克和非诺贝特267毫克。在最后一次食用蘑菇菜肴后的三至六天，采集患者血液样本，检测血清肌酸激酶（CK）、天冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）活性。生化分析采用动力学分光光度法，使用配备雅培专用试剂的全自动生化分析仪Architect ClI8200进行。采用t检验进行统计分析。患者连续四天食用总量为70克至1200克的黄绿蜜环菌，并未导致血清CK、AST、ALT活性显著升高。持续服用他汀类药物或贝特类药物的患者食用类似的蘑菇菜肴，血清CK、AST、ALT活性也未显著升高。服用他汀类药物或贝特类药物的患者可以按照既定传统适量食用黄绿蜜环菌。
