Henriksson B G, Söderström S, Gower A J, Ebendal T, Winblad B, Mohammed A H
Department of Geriatric Medicine, Karolinska Institutet, Huddinge University Hospital, Sweden.
Behav Brain Res. 1992 May 8;48(1):15-20. doi: 10.1016/s0166-4328(05)80134-2.
Brain nerve growth factor (NGF) was determined in two groups of aged rats: 'good' and 'poor' performers. The animals were selected out of a population of 40 aged rats (26-28 months old) trained in a spatial learning task. Animals performing well in the test had significantly higher NGF in the hippocampus when compared to 'poor' performers. No differences in the levels of NGF were found in the cortex, septum and cerebellum. The results implicate hippocampal NGF in cognitive functioning of aged rats, and suggests that the forebrain cholinergic neuronal atrophy which has been observed in cognitively impaired aged rats may be due to reduced availability of target-derived NGF.
在两组老年大鼠（“表现良好”组和“表现较差”组）中测定了脑神经生长因子（NGF）。这些动物是从40只接受空间学习任务训练的老年大鼠（26 - 28个月大）群体中挑选出来的。与“表现较差”的大鼠相比，在测试中表现良好的动物海马体中的NGF含量显著更高。在皮质、隔区和小脑中未发现NGF水平存在差异。这些结果表明海马体NGF与老年大鼠的认知功能有关，并表明在认知受损的老年大鼠中观察到的前脑胆碱能神经元萎缩可能是由于靶源性NGF的可用性降低所致。
