Boyett Mark R, Li Jue, Inada Shin, Dobrzynski Halina, Schneider Jurgen E, Holden Arun V, Zhang Henggui
Division of Cardiovascular and Endocrine Sciences, University of Manchester, M13 9XX Manchester, UK.
J Electrocardiol. 2005 Oct;38(4 Suppl):113-20. doi: 10.1016/j.jelectrocard.2005.06.102.
Since the 1960s, models of the action potential in various cardiac cell types have been developed, and since the 1990s, 3-dimensional anatomic (or geometric) models of various cardiac structures have been developed. We are approaching the time when, for one species, we should have a complete set of action potential and anatomic models for the various cardiac tissues and then we will have realized the aim of constructing a "virtual heart" with accurate anatomy and electrophysiology. However, already the two types of model are beginning to be used in tandem to reconstruct the activation sequence of the heart both during sinus rhythm and arrhythmias.
自20世纪60年代以来,已开发出多种心脏细胞类型的动作电位模型,自20世纪90年代以来,已开发出多种心脏结构的三维解剖(或几何)模型。我们正在接近这样一个时代,即对于某一物种,我们应该拥有一套完整的各种心脏组织的动作电位和解剖模型,届时我们将实现构建一个具有精确解剖结构和电生理功能的“虚拟心脏”的目标。然而,这两种类型的模型已经开始联合使用,以重建窦性心律和心律失常期间心脏的激动顺序。