Sarbassov Dos D, Ali Siraj M, Sabatini David M
Whitehead Institute, MIT Department of Biology, 9 Cambridge Center, Cambridge, Massachussetts 02142, USA.
Curr Opin Cell Biol. 2005 Dec;17(6):596-603. doi: 10.1016/j.ceb.2005.09.009. Epub 2005 Oct 13.
The mammalian TOR (mTOR) pathway is a key regulator of cell growth and proliferation and increasing evidence suggests that its deregulation is associated with human diseases, including cancer and diabetes. The mTOR pathway integrates signals from nutrients, energy status and growth factors to regulate many processes, including autophagy, ribosome biogenesis and metabolism. Recent work identifying two structurally and functionally distinct mTOR-containing multiprotein complexes and TSC1/2, rheb, and AMPK as upstream regulators of mTOR is beginning to reveal how mTOR can sense diverse signals and produce a myriad of responses.
哺乳动物的雷帕霉素靶蛋白（mTOR）信号通路是细胞生长和增殖的关键调节因子，越来越多的证据表明，该信号通路失调与包括癌症和糖尿病在内的人类疾病相关。mTOR信号通路整合来自营养物质、能量状态和生长因子的信号，以调节包括自噬、核糖体生物合成和代谢在内的许多过程。最近的研究确定了两种结构和功能不同的含mTOR多蛋白复合物，以及作为mTOR上游调节因子的TSC1/2、Rheb和AMPK，这开始揭示mTOR如何感知多种信号并产生无数反应。
