利用RNA调控哺乳动物转录
Regulating mammalian transcription with RNA.
作者信息
Corey David R
机构信息
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA.
出版信息
Trends Biochem Sci. 2005 Dec;30(12):655-8. doi: 10.1016/j.tibs.2005.09.007. Epub 2005 Oct 13.
PMID:16226463
Abstract
Recent reports have demonstrated that small duplex RNAs mediate recognition of chromosomal DNA and inhibit transcription within mammalian cells. Key unresolved issues include whether RNAs directly bind to DNA, the identification of the mechanism(s) that convert chromosome recognition into gene silencing and whether naturally occurring antigene RNAs (agRNAs) exist.
摘要
最近的报道表明，小双链RNA介导对染色体DNA的识别并抑制哺乳动物细胞内的转录。尚未解决的关键问题包括RNA是否直接与DNA结合、将染色体识别转化为基因沉默的机制的鉴定以及天然存在的反基因RNA（agRNA）是否存在。
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